Dedicated to enable curative hematopoietic cell transplantation for patients in need

For successful hematopoietic stem cell transplantation, the patient’s diseased blood system needs to be removed to generate space for donor stem cells. This so-called pre-transplantation “conditioning” facilitates the engraftment and regeneration of the donor hematopoietic system in the patient’s body. Today, removing the patient’s hematopoietic stem and progenitor cells requires chemotherapy and in some cases radiation – with possible severe side effects. These side effects prevent elderly or comorbid patients with various malignant and non-malignant blood diseases to receive potentially life-saving hematopoietic stem cell transplantation.

With our T cell engager and activator technology, we aim to develop a safer and more targeted conditioning method with fewer side effects. Thereby, we aim to not only provide a less toxic method for current patients but also increase the total number of patients eligible for hematopoietic stem cell transplantation.